✦ LIBER ✦
Sterically Congested Molecules, 16 A Convenient Synthesis of Di-tert-butyl Ketone via its Imine, 2,2,4,4-tetramethyl-3-pentanimine
✍ Scribed by Knorr, Rudolf ;Donhärl, Angelika ;Hennig, Karsten-Olaf
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 272 KB
- Volume
- 1996
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
2,2,4,4‐Tetramethyl‐3‐pentanimine (3) is efficiently prepared by a Barbier‐type reaction of pivalonitrile (1) with an excess of tert‐butyl chloride (2) and metallic lithium in ether. Its purification by extraction into aqueous acid and slow hydrolysis permit an inexpensive and very simple production of di‐tert‐butyl ketone (4).