Stereospecific synthesis ofα-methylated amino acids
✍ Scribed by S. Mzengeza; T. K. Venkatachalam; M. Diksic
- Book ID
- 106222442
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 101 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0939-4451
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📜 SIMILAR VOLUMES
As part of our program aimed at the design of specific enzyme inhibitors, we have been interested in the synthesis of a-alkyl substituted-u-amino acids of type 1 (Y -H or heteroatom functions). R CH3 The classical route to a-alkyl substituted-a-amino acids consists of a Bucherer or a Strecker reacti
## Abstract A new route to completely protected α‐methylated α‐amino acids starting from alanine is described (see __Scheme__). These derivatives, which are obtained __via__ base‐catalyzed opening of the oxazolidinones (2__S__,4__R__)‐ and (2__R__,4__S__)‐2, can be directly employed in peptide synt