✦ LIBER ✦
Stereospecific synthesis of carbocyclic nucleosides from 2-azabicyclo-[2.2.1]heptan-3-ones via sodium borohydride mediated carbon-nitrogen bond cleavage
✍ Scribed by Nobuya Katagiri; Makoto Muto; Chikara Kaneko
- Book ID
- 104229694
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 245 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
New synthons for carbocyclic nucleosides have been synthesized from 2-azabicyclo[2.2.l]hept-5-en-3-one readily available from cyclopentadiene, through introduction of an electron-withdrawing substituent at the 2-position followed by reduction with sodium borohydride.
Previously, we have synthesized the adducts B by Diels-Alder reaction of