Stereospecific synthesis of a novel bicyclic β-lactam
✍ Scribed by Zbigniew Kaluza; Maghar S. Manhas; Kaled J. Barakat; Ajay K. Bose
- Book ID
- 108477053
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 413 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0960-894X
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Bicyclic thiazolidine lactam 1 was used as a model system for developing synthetic methodology into ~-tm'n mimics that would contain side chain functionality. Treatment of a mixture of 1 and a non-enolizable aldehyde at -100 \*C with LDA resulted in a good yield of the aldol ~d,\_,ct when aromatic a
## Since the discovery (2) of 'I-methoxy cephalosporins and their biological activity considerable attention has been directed towards the synthesis of a-methoxy-8-lactams (3). For some time we have been interested in the synthesis of B-alkoxy-8-lactams and have reported the preparation of one s