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Stereospecific synthesis of 2-phthalimido-2a,3,4,5-tetrahydro-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones

✍ Scribed by Jiaxi Xu; Gang Zuo; Qihan Zhang; Wing Lai Chan

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 125 KB
Volume: 13
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.10029

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✦ Synopsis

Abstract

2a,4‐Disubstituted 2‐phthalimido‐2a,3,4,5‐tetrahydro‐1H‐azeto[2,1‐d][1,5]benzothiazepin‐1‐ones were synthesized by cycloaddition reactions of 2,4‐disubstituted 2,3‐dihydro‐1,5‐benzothiazepines and phthalimidoketene, generated from phthalimidoacetyl chloride, in the presence of triethylamine in anhydrous benzene. The stereochemistry was discussed for the cycloaddition reaction. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:276–279, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10029

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