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Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts

✍ Scribed by Leo G. Abood; Holly G. Atkinson; Mary Macneil

Book ID
102385615
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
284 KB
Volume
2
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a K~d~ of 9 Β· 10^–9^ M. In most respects the binding characteristics resemble those of snyaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca^2+^ and Na^+^; and sensitivity to phospholipases and tryspin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group.

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