Stereospecific friedel-crafts alkylation of benzene with 4-mesyloxy-L-prolines. A new synthesis of 4-phenylprolines

✍ Scribed by D.R. Kronenthal; R.H. Mueller; P.L. Kuester; T.P. Kissick; E.J. Johnson

• Book ID: 104222043
• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 278 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)88775-4

✦ Synopsis

The reaction of benzene with cis-and fruns-N-benzoyl-4-mesyloxy-L-proline (11 and 12) in the p=sence of AlCl3 stereospecifIcally produces the comzspondiug trans-and &4phenylpmline derivatives.

In conuection with the synthesis of trans4phenyl-L-proline. we wem interested in studying the