Stereospecific Enzymatic Transformation of α-Ketoglutarate to (2 S ,3 R )-3-Methyl Glutamate during Acidic Lipopeptide Biosynthesis
✍ Scribed by Mahlert, Christoph; Kopp, Florian; Thirlway, Jenny; Micklefield, Jason; Marahiel, Mohamed A.
- Book ID
- 126402225
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 296 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
4-Alkyl-2-alkylidene-glutaric acids are easily obtained by a Claisen-Johnson rearrangement, providing a short access to 4-alkyl-ot-ketoglutaric acids. These compounds are substrates of the glutamic oxalacetic transaminase (GOT), allowing the enzymatic synthesis of biologically important analogues of
A New Access to Alkyl-α-ketoglutaric Acids, Precursors of Glutamic Acid Analogues by Enzymatic Transamination. Application to the Synthesis of (2S,4R)-4-Propyl-glutamic Acid. -The new ketoglutarate (V) is easily available by a novel route via Claisen-Johnson rearrangement of ester (I) with orthoest