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Stereospecific elimination of deuterium as a method for determining the stereochemistry of a number of metabolites of the tetrahydrocannabinols

✍ Scribed by D. J. Harvey

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
711 KB
Volume
7
Category
Article
ISSN
1076-5174

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✍ Maria Szirmai; Helena Odqvist; Magnus M. Halldin πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 French βš– 773 KB

The first synthesis of 4"-hydroxy-A1-THC-7-oic acid, one of the three major metabolites of AI-THC identified in human urine is discussed. Methyl 4-(3,5-dihydroxyphenyl)butanoate (8) was prepared from 3,5-dihydmxybenzoic acid in an overall yield of 15%. 8 was condensed with a terpene synthon (9) unde