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Stereoselective α-alkylation of ketones and esters using chromiumtricarbonyl-complexed benzyl acetates

✍ Scribed by M.T. Reetz; M. Sauerwald


Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
192 KB
Volume
24
Category
Article
ISSN
0040-4039

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A highly efficient and stereoselective technique for additions to syn-β-alkyl-β-hydroxy-α-methyl ketones is now available. The methodology is based on the conversion of the starting material into a trichlorotitanium alkoxide derivative, which is able to assume a stable cyclic arrangement exhibiting