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Stereoselective Total Synthesis of Bistramide A

✍ Scribed by Yadav, J. S.; Chetia, Lakshindra


Book ID
120241004
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
185 KB
Volume
9
Category
Article
ISSN
1523-7060

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The C1-C13 fragment of bistramide A was prepared from 5-hexenoic acid in 15 linear steps and in 16% overall yield. The core 2,6-trans-tetrahydropyran ring was obtained via a kinetically controlled oxa-Michael cyclization from the corresponding chiral a,b-unsaturated hydroxyester. This precursor was