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Stereoselective Titanium-Mediated syn-Aldol Reaction from a Lactate-Derived Chiral Ethyl Ketone.

✍ Scribed by Joan G. Solsona; Pedro Romea; Felix Urpi


Publisher
John Wiley and Sons
Year
2004
Weight
25 KB
Volume
35
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES


Highly Stereoselective Synthesis of syn-
✍ Judit Esteve; SΓ²nia Matas; Miquel Pellicena; Javier Velasco; Pedro Romea; FΓ¨lix πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 216 KB

## Abstract A sequential transformation based on a titanium‐mediated aldol reaction from chiral α‐__tert__‐butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH~4~ provides a straightforward access to __syn__‐1,3‐diols. These diols, containing up to three new ster