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Stereoselective Synthesis of Unnatural Spiroisoxazolinoproline-Based Amino Acids and Derivatives.

✍ Scribed by Wei-Chieh Cheng; Yannan Liu; Melissa Wong; Marilyn M. Olmstead; Kit S. Lam; Mark J. Kurth


Publisher
John Wiley and Sons
Year
2003
Weight
123 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract This account concentrates on our new methodologies for the synthesis of fluorine analogues of amino acids and their derivatives using the Reformatsky‐type reactions of ethyl bromodifluoroacetate and ethyl dibromofluoroacetate with imines promoted by the Wilkinson catalyst. First, we pre