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Stereoselective synthesis of unnatural aminoacids cis-4-hydroxyproline and bulgecinine

โœ Scribed by Alessandra Madau; Gianni Porzi; Sergio Sandri


Book ID
103977439
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
368 KB
Volume
7
Category
Article
ISSN
0957-4166

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Epoxidation of a series of poly-oxygenated chalcones with H202 in the presence of poly-ctaminoacids yielded chiral aromatic oxygenated oxiranes in moderate to high optical yields. Lewis acid-catalysed phenylmethanethiol ringopening of the epoxide functionality and subsequent formation of the pyranon