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Stereoselective synthesis of the two major metabolites of spironolactone, 3α- and 3β-hydroxy-7α-methylthio-17α-pregn-4-ene-21,17-carbolactone

✍ Scribed by Guo Li; Yan Zhang


Book ID
116892051
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
192 KB
Volume
72
Category
Article
ISSN
0039-128X

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Intramolecular condensation of steroidal
✍ James R Bull; Lynne M Steer 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 193 KB

Intramolecular condensation of steroidal Ilfi-acetoxy-17a-carbaldehydes offers a synthetic route to 19-nor-17,17-spirofactones. A cycloaddition-mediated route to ring D modified 19-not-steroids has recently been described, 2 in which 17~-acetoxy-3-methoxyestra-1,3,5(10)-triene-14,l7a-dicarbaldehyde(