Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide

✍ Scribed by Dirk Brohm; Herbert Waldmann

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 241 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00702-3

✦ Synopsis

The core structure of the protein phosphatase inhibitor dysidiolide and analogs thereof were built up in high yields and with high diastereomer ratios by Diels-Alder reaction between an appropriate diene and an o~,13-unsaturated aldehyde.