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Stereoselective Synthesis of the C1—C13 Fragment of 2,3-Dihydrodorrigocin A (I).

✍ Scribed by Jean-Yves Le Brazidec; Charles A. III Gilson; Marcus F. Boehm


Publisher
John Wiley and Sons
Year
2006
Weight
11 KB
Volume
37
Category
Article
ISSN
0931-7597

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A stereoselective synthesis of all functionalized C2-C10 fragment 13 of the antitumor marine natural product clavulactone was accomplished, starting from the commercially available 3-methylglutaric acid anhydride. Desymmetrization of 3-methylglutaric acid anhydride with (S)-α-phenylethanamine was su