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Stereoselective synthesis of the bis(tetrahydrofuran) moiety (C-1 to C-9) of (+)-asteltoxin, a novel mycotoxin from aspergillus stellatus

✍ Scribed by Kin-ichi Tadano; Hirohiko Yamada; Yoko Idogaki; Seiichiro Ogawa; Tetsuo Suami


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
244 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis


The bis(tetrahydrofuran) moiety of (+)-asteltoxin which possesses six asymmetric carbons has been synthesized stereoselectively.

The synthesis was started from a highly functionalized tetrahydrofuran prepared from P-glucose.

(+)-Asteltoxin (L), which was isolated from cultures of AspergiZZus stellatus Curzi by

Vleggaar and co-workers in 1979,