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Stereoselective synthesis of the 20-hydroxyecdysone side chain

โœ Scribed by Kametani, Tetsuji; Tsubuki, Masayoshi; Furuyama, Hiroko; Honda, Toshio


Book ID
121440417
Publisher
Royal Society of Chemistry
Year
1985
Weight
456 KB
Category
Article
ISSN
1472-7781

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A facile synthesis of the 20-hydroxyecdy
โœ Udo Hedtmann; Peter Welzel ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 118 KB

Key steps of a new synthesis of the ZO-hydroxyecdysone side chain are (i) addition of 2 to ZO-ketopregnanes and (ii) the stereoselective reduction of the 22-keto group after OH group protection. PO-Hydroxyecdysone (IZb) plays a major regulatory role during the postembryonic development of insects an