Stereoselective Synthesis of Tetrahydrofuran Spiro-β-Lactams by Ru-Catalyzed Metathesis of 7-Oxabicyclo[2.2.1]heptenes

✍ Scribed by Aurelio G. Csákÿ; Rocío Medel; M. Carmen Murcia; Joaquín Plumet

• Book ID: 102260194
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: German
• Weight: 213 KB
• Volume: 88
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200590111

✦ Synopsis

Abstract

A new method for the synthesis of spiro‐β‐lactams tethered to tetrahydrofuran rings is described. The procedure is based on Ru‐catalyzed metathesis sequences with oxanorbornene precursors easily obtained by the Staudinger [2+2] cycloaddition of related imines.