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Stereoselective Synthesis of Tetrahydrofuran by Diastereoselective [3 + 2] Cycloaddition Reaction of Chiral Allylsilane with α-Keto Ester.

✍ Scribed by Takahiko Akiyama; Shinya Funaki; Kohei Fuchibe


Publisher
John Wiley and Sons
Year
2006
Weight
21 KB
Volume
37
Category
Article
ISSN
0931-7597

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✍ Hong-Kui Zhang; Wing-Hong Chan; Albert W. M. Leeb; Wai-Yeung Wong 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 445 KB 👁 1 views

## Abstract magnified image Asymmetric 1,3‐dipolar cycloadditions of chiral nitrones to 1‐propene‐1,3‐sultone (**1**) were investigated. Chiral nitrones **6a‐e** reacted with sultone **1** in toluene at 90 °C for 24‐36 h to give the corresponding isoxazolidines in moderate yields with high regiose