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Stereoselective synthesis of steroid side chains: a route to de-AB-cholestan-9-one

✍ Scribed by Takahashi, Takashi; Yamada, Haruo; Tsuji, Jiro


Book ID
120595885
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
345 KB
Volume
103
Category
Article
ISSN
0002-7863

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## Abstract A new method for the synthesis of steroids with oxygenated side chains starting from C~22~ steroids is described. Rieke copper, obtained by reduction of lithium 2‐thienylcyanocuprate 4 with lithium naphthalenide at βˆ’78Β°C or βˆ’100Β°C, reacts with the 22‐bromosteroids 1a, 2, 14 to afford th