Stereoselective Synthesis of ( R )- and ( S )-4-Methoxydalbergione via Asymmetric Catalytic Hydrogenation
✍ Scribed by Bissel, Philippe; Nazih, Abdesslame; Sablong, Rafaël; Lepoittevin, Jean-Pierre
- Book ID
- 127251723
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 45 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1523-7060
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Compound 7, a precursor in the synthesis of 4-methoxybalbergione, was prepared from compound 6 with an enantiomeric excess of 17 to 94% by asymmetric catalytic hydrogenation using rhodium or ruthenium chiral complexes. The best hydrogenation results were obtained using [Rh((S,S)-bdpp)(NBD)1 Cl04, an
The asymmetric hydrogenation of a dihydropyrrolo-benzothiadiazine dioxide 1 with a diphosphine ruthenium diamine catalyst has been used to synthesize the AMPA receptor positive modulator tetrahydropyrrolo-benzothiadiazine dioxide 2 (S 18986) in high enantiomeric excess. The use of factorial experime