𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Stereoselective synthesis of protected (2S,3S)-N-methyl-5-hydroxyisoleucine, a component of halipeptins

✍ Scribed by Sousuke Hara; Kazuishi Makino; Yasumasa Hamada


Book ID
108282680
Publisher
Elsevier Science
Year
2004
Tongue
French
Weight
241 KB
Volume
60
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


A Practical and Efficient Total Synthesi
✍ Sandra De Lamo Marin; CΓ©dric Catala; Sreekantha Ratna Kumar; Alain Valleix; Alai πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 145 KB πŸ‘ 1 views

## Abstract (2__S__,3__R__,4__S__)‐4‐Hydroxyisoleucine, which exhibits remarkable insulinotropic activity, is expected to be a potent drug to treat type II diabetes. We propose herein a four‐step synthesis of the enantiopure natural product on the basis of successive Mannich condensation, catalytic

Stereoselective synthesis of (2S,3S,4R,5
✍ Makoto Oba; Tsutomu Terauchi; Jun Hashimoto; Tomohiro Tanaka; Kozaburo Nishiyama πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 227 KB

A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct

The efficient stereoselective synthesis
✍ Shigekazu Sasaki; Yasumasa Hamada; Takayuki Shioiri πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 216 KB

The title acid, a component of microsclerodermins of marine sponge origin having five consecutive stereogenic centers, was efficiently synthesized as its protected form 1 from the alcohol 5 utilizing the stereoselective addition of anisole to the acetylenic triple bond and the anti-aldol reaction as