A facile synthesis of a series of naphtho[2,1-b]pyrano pyrrolizidines and indolizidines was accomplished in good yields in a one-pot reaction through intramolecular 1,3-dipolar cycloaddition of azomethine ylides with Baylis-Hillman adducts as dipolarophiles. The protocol is applicable to a wide vari
โฆ LIBER โฆ
Stereoselective synthesis of novel glyco-pyrano pyrrolidines/pyrrolizidines/indolizidines through intramolecular [3+2] cycloaddition approach
โ Scribed by N. Sirisha; R. Raghunathan
- Book ID
- 104097592
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 379 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
An efficient and stereoselective synthesis of novel furo-pyrano pyrrolidine/pyrrolizidine/indolizidine derivatives has been achieved by intramolecular [3+2] cycloaddition reaction of azomethine ylide generated in situ from O-allyl sugar-derived aldehyde and different secondary amino acids.
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