Stereoselective synthesis of (−)-N-Boc-statine and (−)-N-Boc-Norstatine
✍ Scribed by G. Veeresha; Apurba Datta
- Book ID
- 104257464
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 128 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
An efficient synthesis of optically pure N-Boc-statine ( 9) and N-Boc-norstatine (11) has been developed v/a a syn selective Grignard reaction of N-Boc-leucinal with allyl-or vinylmagnesium bromide.
📜 SIMILAR VOLUMES
Alkylation of ¢nolates of mcvvsubstituted N-BOc Iactams 4-6 afforded trans-disubstituted lactams as the major is~ner. In the pyrrolidinon¢ sa'ies, 1,3-induction seems to be ruled by stetic interacti~s and the diasterc~electi~m is low fc¢ the alkylation of enolates with small substitumts at C-5 (e.&,
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