Stereoselective synthesis of hydroxypyrrolidines and hydroxypiperidines by cyclization of γ-oxygenated-α,β-unsaturated sulfones
✍ Scribed by Juan Carlos Carretero; Ramón Gómez Arrayás; Isabel Storch de Gracia
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 242 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
E)-3-Hydroxy-l-dkenyl p-tolyl sulianes (1) reacted with a hexaluoropropene-.diethylamine adduet (PPDA) to aflbrd ct-fluora-ct-(trilluoromethyi)-l~-[(p-tulylsullanyl)methyl].ff-laetones (2). This reaction is so steteoselective that only one diastel'eomer of 2 is detected in the reaction mixttt~. A pl
## Abstract α,β‐γ,δ‐Unsaturated sulfones and sulfoxides have been prepared via the Horner‐Emmons reaction of α,β‐unsaturated carbonyl compounds with α‐phosphoryl sulfones and sulfoxides.
## Abstract (2E)‐α‐Amido‐α,β‐unsaturated sulfones, which are easily prepared by the condensation of α‐amido‐sulfones with aldehydes, can be desulfonylated by sodium hydrogen telluride to give (2Z)‐cinnamanilides with excellent stereoselectivity and in good yields.