Stereoselective synthesis of (−)-homogynolide-A
✍ Scribed by Benoît Hartmann; Alice M. Kanazawa; Jean-Pierre Deprés; Andrew E. Greene
- Book ID
- 104215876
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 146 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A Formal Total Synthesis of (±)-Homogynolide-B. -The key intermediate keto ketals (III) and (IV), derived from ester (I), are further converted in a separate way to the target spirolactone (XIII), the Greene's precursor of homogynolide-B. The 5-exo-dig radical cyclization of the bromo acetal (X) fo
A short synthesis of racemic homogynolide-B is described. The key step of the approach, cycloaddition of dichloroketene with the 2,2-dimethyltrimethylene acetal of 2,3-dimethyl-3-cyclohexen-l-one, proceeds with excellent selectivity and in high yield. The bakkanes, a relatively small group of hydri