Stereoselective synthesis of exocyclic alkenes via zirconium-promoted alkyl-diene coupling
โ Scribed by Negishi, Eiichi; Miller, Steven R.
- Book ID
- 126023975
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 344 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Treatment of stereodefined w-halo-2-iodoalkene derivatives (l), prepared via stereoselective addition reactions of alkynes, with either n\_BuLi (1 equiv) or t-BuLi (2 equiv) can produce exccyclic alkenes whose isomeric purity is essentially 100%.
A stereoselective method for the preparation of dibenzoxapine containing tetrasubstituted exocyclic E-alkenes has been developed. The key reaction involves an intramolecular cyclocarbopalladation of alkynes to form a vinylpalladium species and subsequently coupling the vinylpalladium with methylboro