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Stereoselective synthesis of enantiopure 4,5-disubstituted pyrrolidin-2-ones by consecutive cuprate addition and N-acyliminium coupling

โœ Scribed by Wim-Jan Koot; Henk Hiemstra; W.Nico Speckamp


Book ID
104214801
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
295 KB
Volume
33
Category
Article
ISSN
0040-4039

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Chirospecific synthesis of trans-2,5-dis
โœ Lars-G. Wistrand; Marco Skrinjar ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 695 KB

Reaction of the N-acyliminium ion pmcursor la &??Wedjhm S-proline via anodic methoxykation~ with RCu in the pnsetue of BF,.Et# gives preferentially the trans adducts 2 (trans:ci.s L96:4). Using such a procedure, a general synthetic route to (2R, 5.~~-hans-2,5-d~l~~~l~ines has been developed, as ezmp