1,2-Di-O-isopropylidene-3-C-cyanoethyl-5-deoxy-5-isopropylamino-D-xylofuranose 16a was synthesized. The use of 16a as a chiral auxiliary led to the diastereoselective formation of dithymidine phosphorothioate. The chiral auxiliary was easily removed by treatment with concentrated ammonia. 2-Mesityl-
Stereoselective Synthesis of Dithymidine Phosphorothioates Using Xylose Derivatives as Chiral Auxiliaries
β Scribed by Jin, Yi; Just, George
- Book ID
- 126781569
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 122 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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