Stereoselective synthesis of d-erythro- and l-threo-sphinganines via palladium-catalyzed equilibration and Suzuki coupling

✍ Scribed by Gregory R. Cook; Ketheeswaran Pararajasingham

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 209 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02309-2

✦ Synopsis

The Pd-catalyzed isomerization of 5-vinyloxazolines was utilized for the stereoselective synthesis of D-erythro -and L-threo -spinganine triacetate. A hydroboration/Suzuki coupling sequence was employed to elongate the hydrophobic chain.