Stereoselective synthesis of thienyl and
✍
Franz Effenberger; Joachim Eichhorn
📂
Article
📅
1997
🏛
Elsevier Science
🌐
English
⚖ 503 KB
The stereoselective syntheses of thienyl and furyl analogues of ephedrine starting from (R)-and (S)-cyanohydrins, respectively, are described. Addition of methyl Grignard to the O-trimethylsilyl protected optically active cyanohydrins (R)-and (S)-3 and hydrogenation of the resulting imino intermedia