Chiral bicyclic piperidine derivatives are important pharmacophoric structural elements. Despite its undesired side effects, morphine 1, the prototype of current opiod analgesics,
Stereoselective Synthesis of Chiral Piperidine Derivatives Employing Arabinopyranosylamine as the Carbohydrate Auxiliary.
โ Scribed by Birgit Kranke; Horst Kunz
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 34 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A 2,3,4โtriโ__O__โpivaloylated ฮฒโDโgalactopyranosyl azide bearing a hydroxyโfunctionalized spacer unit at the Cโ6 position of the galactose was synthesized and immobilized on the solid phase by using a polymerโbound chlorosilane. The azide was reduced to the corresponding galactopyranos
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