Stereoselective synthesis of both diastereomers of the .alpha.-methyl-.beta.-hydroxy-.beta.-alkyl(aryl) units by use of tin(II) triflate-mediated aldol reaction

Enantioselective synthesis of both diast

Enantioselective synthesis of both diastereomers, including the α-alkoxy-β-hydroxy-β-methyl(phenyl) units, by chiral tin(II) Lewis acid-mediated

✍ Shū Kobayashi; Mineko Horibe; Yumi Saito 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 967 KB

## Diastereo-and enantioselective synthesis of both diastereomers, including the aalkoxy-f&hydroxy-B-methyl(pheny1) units, was performed by using chiral tin(ll) Lewis acidmediated asymmetric aldol reactions of a-alkoxy silyl en01 ethers with a-ketoesters. (S-l-Propyl-2- [(1,2,3,4-tetrahydroisoqui