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Stereoselective synthesis of amino-substituted apio dideoxynucleosides through a distant neighboring group effect

✍ Scribed by Won Jun Choi; Hee Sung Ahn; Hea Ok Kim; Sanghee Kim; Moon Woo Chun; Lak Shin Jeong

Book ID: 104251674
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 71 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01295-9

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✦ Synopsis

Novel amino-substituted apio nucleoside (2R,4R)-LJ-45 as a potential anti-HBV agent was stereoselectively synthesized from the known oxazolidine 1 through a distant neighboring group effect. It is believed that this synthetic method using a chiral template, (-)-L-serine methyl ester can be generally applied to the synthesis of other chiral amino-substituted nucleosides.

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