✦ LIBER ✦
Stereoselective synthesis of alcohols, XLI. Chirality transfer to generate quaternary stereogenic centers by an allylboration reaction
✍ Scribed by Hoffmann, Reinhard W. ;Schlapbach, Achim
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 399 KB
- Volume
- 1991
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The acyclic alcohols 13 and 14 having a neighboring quaternary stereogenic center can be obtained in diastereoselectivities of > 95% by addition of the ß,γ,γ‐trisubstituted allylboronates 12 to aldehydes. Starting from the nonracemic allylboronates 19 of presumed 84–92% e.e., we have obtained the alcohols 13a and 14a with the corresponding levels of the e.e.