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Stereoselective synthesis of a pyridoxamine coenzyme-amino acid chimera: Assembly of a polypeptide incorporating the pyridoxamine moiety

โœ Scribed by Ranabir Sinha; Barbara Imperiali


Book ID
103408938
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
241 KB
Volume
37
Category
Article
ISSN
0040-4039

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Stereoselective synthesis of the hydroxy
โœ Akiyoshi Kawai; Osamu Hara; Yasumasa Hamada; Takayuki Shioiri ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 222 KB

The hydroxy amino acid moiety of AI-77-B (1) has been prepared as its protected form 2 from the (R)-glyceric acid derivative 3 in an efficiently stereoselective manner through the direct C-acylation using diphenyl phosphorazidate and the hydroxy-directed hydrogenation. Al-77-B having a unique gastr