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Stereoselective Synthesis of 3,3-Diarylacrylonitriles as Tubulin Polymerization Inhibitors

โœ Scribed by Fang, Zhenglai; Song, Yunlong; Sarkar, Taradas; Hamel, Ernest; Fogler, William E.; Agoston, Gregory E.; Fanwick, Phillip E.; Cushman, Mark


Book ID
120442515
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
509 KB
Volume
73
Category
Article
ISSN
0022-3263

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Stereoselective synthesis of tubuvaline
โœ Taku Shibue; Toshihiro Hirai; Iwao Okamoto; Nobuyoshi Morita; Hyuma Masu; Isao A ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 561 KB

Synthetic studies of two components of tubulysins, tubulin polymerization inhibitors are described. The highly stereoselective synthesis of tubuvaline methyl ester (2) was accomplished by 1,3-dipolar cycloaddition of nitrone D-6 and acrylic acid derivatives 7 as a key step. The synthesis of tubuphen