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Stereoselective synthesis of 3-fluoro azetidinones via the condensation of 2-fluoropropanethioate lithium enolate with imines

✍ Scribed by Takashi Ishihara; Kazuyoshi Ichihara; Hiroki Yamanaka


Book ID
107857692
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
520 KB
Volume
52
Category
Article
ISSN
0040-4020

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Diastereo- and enantio-selective synthes
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## Abstract Zinc enolates of phenyl‐ and __trans__‐styryl‐acetic acid methyl ester react with excellent diastereoselectivety and good enantioselectivety (e.e. 64 to 91.5%) with imines in high yields to __trans__‐2‐azetidinones. The corresponding lithium enolates reacted with much lower selectivity