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Stereoselective synthesis of (2R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylaminohex-4-ynoic Acid

✍ Scribed by Dirk Heerding; Pradip Bhatnagar; Michael Hartmann; Peter Kremminger; Stephen LoCastro


Book ID
108036381
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
192 KB
Volume
7
Category
Article
ISSN
0957-4166

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✍ Ernesto G. Occhiato; Dina Scarpi; Antonio Guarna 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 1 views

## Abstract A new synthetic route to enantiopure (2__S__,4__R__)‐4‐hydroxypipecolic acid from commercial ethyl (3__S__)‐4‐chloro‐3‐hydroxybutanoate is reported. The synthesis is based on the Pd‐catalyzed methoxycarbonylation of a 4‐alkoxy‐substituted δ‐valerolactam‐derived vinyl triflate followed b