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Stereoselective Synthesis of 2‘,3‘-Dideoxynucleosides by Addition of Selenium Electrophiles to Glycals. A Formal Synthesis of D4T from 2-Deoxyribose

✍ Scribed by Díaz, Yolanda; El-Laghdach, Anas; Matheu, M Isabel; Castillón, Sergio


Book ID
127314742
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
217 KB
Volume
62
Category
Article
ISSN
0022-3263

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The Michael addition of lithium or magnesium organocuprates and sodium dimethyl malonate to 2-alkylated 3,4-didehydropymglutamates 7, prepared from the corresponding 4-substituted sulfoxides pyroglutamates or from benzophenone imine of glycine ethyl ester or nittile, takes place in a stereoselective