## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of 1,3- anti Diols by an Ipc-Mediated Domino Aldol-Coupling/Reduction Sequence
✍ Scribed by Dieckmann, Michael; Menche, Dirk
- Book ID
- 119948716
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 493 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Chx 2 BCl-mediated syn-aldol reaction of the a-OTBS lactate-derived ketone 1 followed by in situ reduction of the resulting boron aldolate with LiBH 4 lead to complete stereoselectivity for the boronates 2 in 80-95% yields. Then, a very mild oxidative work-up of 2 (H 2 O 2 /NaOAc in THF-H 2 O) allow
## Abstract A sequential transformation based on a titanium‐mediated aldol reaction from chiral α‐__tert__‐butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH~4~ provides a straightforward access to __syn__‐1,3‐diols. These diols, containing up to three new ster