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Stereoselective Synthesis of 1,2- and 1,4-Dihydropyridines by Using Cation-π Interaction as a Conformation-Controlling Tool.

✍ Scribed by Shinji Yamada; Momoe Saitoh; Tomoko Misono


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
33
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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N-t-Butylacetamidines 1 on heating with methyl vinyl ketone, acrolein or crotonaldehyde gave the 2,3-dihydropyridine derivatives 4, 5 or 6 via N-alkylation of the acetamidines 1. Reaction of amidines 1 with phenyl 1-propenyl ketone, benzalacetone or chalcone gave 3,4-dihydropyridine derivatives 8, 9