Stereoselective syntheses of 1,24-dihydroxy squalene 2,3;22,23-dioxides by double sharpless epoxidation

✍ Scribed by Roland Hauptfleisch; Burchard Franck

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 181 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02332-5

✦ Synopsis

A few step synthesis of the (all-E) squalene diol l0 from squalene 4, its double Sharpless epoxidation to the (-)-dihydroxy squalene 2,3;22,23-dioxide 3a, its enantiomer 3b, and the formation ofa tetradeutero derivative 12 is described.