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Stereoselective saluretic effect and localization of renal tubular secretion of enantiomers of S-8666, a novel uricosuric antihypertensive diuretic

โœ Scribed by Masuhisa Nakamura; Tomoji Kawabata; Takako Itoh; Kenji Miyata; Hiroshi Harada


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
694 KB
Volume
19
Category
Article
ISSN
0272-4391

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Stereoselective pharmacokinetics of a no
โœ Kazutaka Higaki; Kyoko Kadono; Masayuki Nakano ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 601 KB

5-Dimethylsulfamoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxyli c acid (DBCA), a promising uricosuric, diuretic, and antihypertensive agent, was administered intravenously to rats. The levels of DBCA in plasma and the areas under the curve of concentration versus time (AUC values) of the S(-)-ena