Stereoselective reductive radical cyclization of ketonitriles catalyzed by Cp2TiCl2 in the presence of chlorosilane and zinc
β Scribed by Longhu Zhou; Toshikazu Hirao
- Book ID
- 108371300
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 134 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
Bis(cyclopentadienyl) titanium dichloride (Cp2TiCI2) exhibits excellent catalytic activity toward the pinacol-type coupling reaction of aliphatic aldehydes with the assistance of zinc powder and chlorosilane.
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A catalytic cyclodimerization of arylidene malononitriles proceeded diastereoselectively with reversible redox between vanadium and zinc in the presence of chlorotrimethylsilane. The reductive coupling reaction strongly depended on the co-reductant, additive, solvent, and substrate.