Stereoselective reduction of α-cyclopropyl ketones and α-cyclopropyl aldols. Stereo-directing effect by α-trimethylsilyl group

Stereospecific 1,2-rearrangement of cycl

Stereospecific 1,2-rearrangement of cyclopropyl group. Synthesis of chiral α-cyclopropyl ketones and α-cyclopropyl aldols

✍ Masato Shimazaki; Hisaaki Hara; Keisuke Suzuki 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 294 KB

Stereospecific 1,2-rearrangement of cyclopropyl group is described as an efficient route to stereo-defined a-cyclopropyl ketones and cr-cyclopropyl aldols. Acceleration of the reaction by the introduction of trimethylsilyl (TMS) group to the a-position of cyclopropyl group is also noted. ## Cyclop