Stereoselective reaction of a chiral assisted amide enolate ion with 1-iodonaphthalene by the SRN1 mechanism
β Scribed by Guillermo A. Lotz; Sara M. Palacios; Roberto A. Rossi
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 169 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Reaction of chiral amide e&ate L&I with (S)-iyci&l tosylate I1 qj?ordt the epoxide 3 in 72% yield with high diastereoselectivity. Epoxide 3 is converte % to the orally-active WV-I protease inhibitor L-735,524 in 71% isolated yield. Hydroxyetbylene dipeptide isosteres which contain the 1S,2R-1-a