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Stereoselective Preparation of Deuterium-Labeled Sugars: (6 R )-(6- 2 H 1 )- N -Acetylglucosamine Derivatives
β Scribed by Falcone-Hindley, Margaret L.; Davis, Jeffery T.
- Book ID
- 118121242
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 112 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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A procedure for deuterium and tritium labeling of the titled compound, an analgesic agent, was developed. A secondary amine intermediate was acylated to an acylamide, then the carbonyl function was reduced by LiAlD 4 to yield the tertiary amine. In the tritium-labeled synthesis, the process utilized